The Yeast Intein Database

The Yeast Intein Database is a comprehensive and curated database devoted to yeast inteins.


Inteins are self-catalytic protein splicing elements. The Yeast Intein Database and Registry, is a curated compilation of published and unpublished information about protein splicing. It presents general information as well as detailed data for each yeast intein, including tabulated comparisons and a comprehensive bibliography. An intein-specific BLAST server is now available to assist in identifying new inteins.

 

Intein Name Sce VMA
Intein id YSTIN025
Intein Class Experimental
Prototype Allele Sce VMA
Organism Name Saccharomyces cerevisiae (nucleus)
Exiein Name Vacuolar ATPase (H+-transporting ATP synthase), subunit A
Intein Class Experimental
Organism Description Yeast, also in Sce strains OUT7163, OUT7045, OUT7163, IFO1992
Domain of Life Eucarya
Endonuclease Activity PI-SceI
Endonuclease Motif DOD
Location in Extein G283
Inert Site Comment VMA-a
Intein Size 454
Intein N Terminal SNSDAIIYVG/C
Intein C Terminal HN/CGERGNEMAE
Accession No PXBYVA in NCBI/protein
Intein aa Sequence >gi|67951|pir||PXBYVA Sce VMA intein (including -1 and +1 extein residues) GCFAKGTNVLMADGSIECIENIEVGNKVMGKDGRPREVIKLPRGRETMYSVVQKSQHRAHKSDSSREVPE LLKFTCNATHELVVRTPRSVRRLSRTIKGVEYFEVITFEMGQKKAPDGRIVELVKEVSKSYPISEGPERA NELVESYRKASNKAYFEWTIEARDLSLLGSHVRKATYQTYAPILYENDHFFDYMQKSKFHLTIEGPKVLA YLLGLWIGDGLSDRATFSVDSRDTSLMERVTEYAEKLNLCAEYKDRKEPQVAKTVNLYSKVVRGNGIRNN LNTENPLWDAIVGLGFLKDGVKNIPSFLSTDNIGTRETFLAGLIDSDGYVTDEHGIKATIKTIHTSVRDG LVSLARSLGLVVSVNAEPAKVDMNGTKHKISYAIYMSGGDVLLNVLSKCAGSKKFRPAPAAAFARECRGF YFELQELKEDDYYGITLSDDSDHQFLLANQVVVHNC
Block A CFAKGTNVLMADG 13
Block B LLKFTCNATHELVV 83
Block C LLGLWIGDG 219
Block D VKNIPSFL 307
Block E FLAGLIDSDG 327
Block H TIHTSVRDGLVSLARSLGL 359
Block F YGITLS**DDSDHQFL 445
Block G NQVVVHNC 455
Contributed by Yasuhiro Anraku
Comments Sce VMA is a nuclear gene. An identical intein aa sequence is present in strain Out7163, (BAC66646.1), OUT7045 (BAC6664), OUT7163 (BAC66646),IFO1992 (BAC66650). Also see AAA34664 NCBI/protein
References Shih 1988 Hirata 1990 Kane 1990 Hirata 1992 Bremer 1992 Ryan 1992 Gimble 1992 Cooper 1993 Gimble 1993 Anraku 1994 Gimble 1995 Gimble 1996 Chong 1996 Kawasaki 1996 Wende 1996 Chong 1997 Chong 1997B Duan 1997 Kawasaki 1997 Kawasaki 1997B Nogami 1997 He 1998 Chong 1998 Grindl 1998 Muir 1998 Pingoud 1998 Severinov 1998 Chong 1998B Cotton 1999 Xu 1999 Yu 1999 Pingoud 1999 Hu 1999 Miyamoto 1999 Hu 2000 Poland 2000 Gimble 2001 Mizutani 2002 Posey 2002 Morassutti 2002 Moure 2002 Werner 2002 Nogami 2002 Okuda 2003 Fukuda 2003 Gimble 2003 Steuer 2004 Mizutani 2004 Anraku 2005

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