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  SNO ProBase, The SNO Proteome knowledgeBase
  SNO ProBase is a comprehensive and curated database devoted to SNO Activity showing protein sequence
  When referencing SNO ProBase, please use the following SNO ProBase Reference:

  Bibliography
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3. Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol 6: 150-66. (2005).

4. Nitrosative Stress in the ER: A New Role for S-Nitrosylation in Neurodegenerative Diseases. ACS Chem Biol 1: 355-8. (2006).

5. Basal and stimulated protein S-nitrosylation in multiple cell types and tissues. J Biol Chem 277: 9637-40. (2002).

6. S-nitrosylation is emerging as a specific and fundamental posttranslational protein modification: head-to-head comparison with O-phosphorylation.
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7. Shear stress increases the amount of S-nitrosylated molecules in endothelial cells: important role for signal transduction.
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8. Further evidence that rat liver microsomal glutathione transferase 1 is not a cellular protein target for S-nitrosylation.
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9. S-Nitrosylation: NO-Related Redox Signaling to Protect Against Oxidative Stress. Antioxid Redox Signal 8 (9-10): 1693-705. (2006).

10. Say NO to Neurodegeneration: Role of S-Nitrosylation in Neurodegenerative Disorders. Neurosignals 15: 307-313. (2007).

11. Protein S-nitrosylation: A role of nitric oxide signaling in cardiac ischemic preconditioning. Sheng Li Xue Bao 59: 544-52. (2007).

12. Studying the S-nitrosylation of model peptides and eNOS protein by mass spectrometry. Nitric Oxide 13: 176-87. (2005).

13. S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. J Biol Chem 280: 7511-8. (2005).

14. Fas-induced caspase denitrosylation. Science 284: 651-4. (1999).

15. S-nitrosylation of microtubule-associated protein 1B mediates nitric-oxide-induced axon retraction. Nat Cell Biol. 9(9):1035-45. (2007).

16. S-Nitrosylation of mitochondrial caspases. J Cell Biol 154: 1111-6. (2001).

17. Identification of the Cysteine Nitrosylation Sites in Human Endothelial Nitric Oxide Synthase. DNA Cell Biol. 2007 Oct 17;
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18. Human spermatozoa contain multiple targets for protein S-nitrosylation: An alternative mechanism of the modulation of sperm function
       by nitric oxide? Proteomics. Sep;7(17):3066-84. (2007).

19. S-nitrosylation of IRP2 regulates its stability via the ubiquitin-proteasome pathway. Mol Cell Biol 24: 330-7. (2004).

20. S-nitrosylation: a potential new paradigm in signal transduction. Cardiovasc Res 62: 43-52. (2004).

21. New insights into protein S-nitrosylation. Mitochondria as a model system. J Biol Chem 279: 25891-7. (2004).

22. S-nitrosylation of proteins. Cell Mol Life Sci 55: 1036-42. (1999).

23. Proteomic identification of S-nitrosylated proteins in Arabidopsis. Plant Physiol 137: 921-30. (2005).

24. A Novel Approach to Identify Proteins Modified by Nitric Oxide: the HIS-TAG Switch Method. J Proteome Res. 6(8):3224-31. (2007).

25. S-Nitrosylation: an emerging redox-based post-translational modification in plants. J Exp Bot 57(8):1777-84 (2006).

26. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science 297: 1186-90. (2002).

27. An autocatalytic mechanism of protein nitrosylation. Proc Natl Acad Sci U S A 97: 13543-8. (2000).

28. Assessment of S-nitrosothiols on diaminofluorescein gels. Anal Biochem 346: 69-76. (2005).

29. In situ detection and visualization of S-nitrosylated proteins following chemical derivatization: identification of Ran GTPase as a target
     
 for S-nitrosylation. Nitric Oxide 11: 216-27. (2004).

30. Regulation and specificity of S-nitrosylation and denitrosylation. ACS Chem Biol 1: 615-8. (2006).

31. S-nitrosothiol depletion in amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 103: 2404-9. (2006).

32. High glucose attenuates protein S-nitrosylation in endothelial cells: role of oxidative stress. Diabetes. 56(11):2715-21. (2007).

33. Nitric oxide inhibits c-Jun N-terminal kinase 2 (JNK2) via S-nitrosylation. Biochem Biophys Res Commun 247: 809-13. (1998).

34. Inducible NO Synthase Dependent S-Nitrosylation and Activation of Arginase1 Contribute to Age-Related
       Endothelial Dysfunction. Circ Res 101(7):692-702. (2007).

35. S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense.
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36. Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. Nitric Oxide 12: 121-6. (2005).

37. S-nitrosylation/Denitrosylation and Apoptosis of Immune Cells. Cell Mol Immunol 4: 353-358. (2007).

38. S-nitrosylation in Parkinson's disease and related neurodegenerative disorders. Methods Enzymol 396: 139-50. (2005).

39. Regulation of apoptosis by nitrosative stress. J Biochem Mol Biol 35: 127-33. (2002).

40. Nitric oxide protects against mitochondrial permeabilization induced by glutathione depletion: role of S-nitrosylation?
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41. Immunoregulatory and antimicrobial effects of nitrogen oxides. Proc Am Thorac Soc 3: 161-5. (2006).

42. Accumulation of misfolded protein through nitrosative stress linked to neurodegenerative disorders.
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43. Mechanism of extracellular thiol nitrosylation by N(2)O(3) produced by activated macrophages. Nitric Oxide 3: 467-72. (1999).

44. Mechanism of p21Ras S-nitrosylation and kinetics of nitric oxide-mediated guanine nucleotide exchange. Biochemistry 43: 2314-22. (2004).

45. Differential effects of nitric oxide-mediated S-nitrosylation on p50 and c-jun DNA binding. Surgery 124: 137-41;
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46. Subcellular targeting and differential S-nitrosylation of endothelial nitric-oxide synthase. J Biol Chem 281: 151-7. (2006).

47. Receptor-regulated dynamic S-nitrosylation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem
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48. Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment.
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49. Preconditioning Results in S-Nitrosylation of Proteins Involved in Regulation of Mitochondrial Energetics and Calcium Transport.
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50. Non-heme iron protein: a potential target of nitric oxide in acute cardiac allograft rejection. Proc Natl Acad Sci U S A 100: 3125-30. (2003).

51. Regulation of beta-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2. Cell 129: 511-22. (2007).

52. Nitrite catalyzes ferriheme protein reductive nitrosylation. J Am Chem Soc 125: 10510-1. (2003).

53. Gel electrofocusing method for studying protein S-nitrosylation. Methods Enzymol 301: 145-51. (1999).

54. Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol 3: 193-7. (2001).

55. Regulation of S-thiolation and S-nitrosylation in the thiol/nitric oxide system by radical scavengers. Nitric Oxide 16(3):356-61. (2007).

56. S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding.
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57. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities.
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58. Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue.
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59. Differential inhibition of Arabidopsis methionine adenosyltransferases by protein S-nitrosylation. J Biol Chem 281: 4285-91. (2006).

60. Nitric oxide regulates endocytosis by S-nitrosylation of dynamin. Proc Natl Acad Sci U S A 103: 1295-300. (2006).sssss

61. In vivo regulation by glutathione of methionine adenosyltransferase S-nitrosylation in rat liver. J Hepatol 31: 887-94. (1999).

62. NOS2 regulation of NF-kappa B by S-nitrosylation of p65* J Biol Chem 282(42):30667-72. (2007).

63. S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation: A novel anti-apoptotic mechanism that suppresses apoptosis.
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64. Detection and identification of S-nitrosylated proteins in endothelial cells. Methods Enzymol 396: 131-9. (2005).

65. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 304: 1328-31. (2004).

66. Nitrosative Stress and Pathogenesis of Insulin Resistance. Antioxid Redox Signal 9(3):319-29. (2007).

67. Crystal structure of the S-nitroso form of liganded human hemoglobin. Biochemistry 37: 16459-64. (1998).

68. Suppression of neuronal apoptosis by S-nitrosylation of caspases. Neurosci Lett 236: 139-42. (1997).

69. Balancing reactivity against selectivity: The evolution of protein S-nitrosylation as an effector of cell signaling by nitric oxide.
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70. Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective
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71. Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol 2(11):570-1. (2006).

72. Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation: Involvement of inducible nitric
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73. Nitric oxide inhibits myocardial apoptosis by preventing caspase-3 activity via S-nitrosylation. J Mol Cell Cardiol 38: 163-74. (2005).

74. Proteomic analysis of S-nitrosylated proteins in mesangial cells. Mol Cell Proteomics 2: 156-63. (2003).

75. Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically
       induced oxidative stress. J Biol Chem 282(19):13977-83. (2007).

76. Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange.
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77. Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase.
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78. Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes.
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79. Metacaspase activity of Arabidopsis thaliana is regulated by S-nitrosylation of a critical cysteine residue. J Biol Chem (2007).

80. Nitric oxide can inhibit apoptosis or switch it into necrosis. Cell Mol Life Sci 57: 612-22. (2000).

81. A novel scavenger of nitric oxide decreases heme protein nitrosylation and prolongs graft survivial during cardiac transplant rejection.
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82. Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells.
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83. Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol.
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84. Regulation of MyD88-dependent signaling events by S-nitrosylation retards Toll-like receptor signal transduction and initiation of
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85. Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by
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86. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme.
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87. Nitric oxide, S-nitrosylation and neurodegeneration. Cell Mol Biol (Noisy-le-grand) 51: 247-54. (2005).

88. Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nat Neurosci 3: 15-21. (2000).

89. Alteration of NF-kappa B p50 DNA binding kinetics by S-nitrosylation. Biochem Biophys Res Commun 238: 703-6. (1997).

90. Cys25-nitrosylation inactivates papain. Biochem Mol Biol Int 46: 425-8. (1998).

91. Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation. Trends Neurosci 25: 474-80. (2002).

92. Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases
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93. Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator.
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94. Detection and characterization of protein nitrosothiols. Methods Enzymol 396: 105-18. (2005).

95. Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation. J Biol Chem 280: 14453-61. (2005).

96. Inhibition of AtMYB2 DNA-binding by nitric oxide involves cysteine S-nitrosylation. Biochem Biophys Res Commun 361(4):1048-53. (2007).

97. Nitric oxide: a signal for ADP-ribosylation of proteins. Life Sci 54: 61-70. (1994).

98. Nitric oxide transfer from the NO-donor S-nitroso-N-acetylpenicillamine to monomers and dimers of water-soluble iron-porphyrins.
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99. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature 441: 513-7. (2006).

100. Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69. Nat Cell Biol 4: 743-9. (2002).

101. S-nitrosylation in health and disease. Trends Mol Med 9: 160-8. (2003).

102. NMDA Receptor-Nitric Oxide Transmission Mediates Neuronal Iron Homeostasis via the GTPase Dexras1. Neuron 51: 431-40. (2006).

103. Inhibition of NF-kappa B by S-nitrosylation. Biochemistry 40: 1688-93. (2001).

104. Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells.
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105. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol 7: 665-74. (2005).

106. S-Nitrosylation of Platelet alpha(IIb)beta(3) As Revealed by Raman Spectroscopy. Biochemistry [Epub ahead of print]. (2007).

107. S-nitrosylation of NSF controls membrane trafficking. Cell 115: 127-9. (2003).

108. Electrochemical and spectral studies on the reductive nitrosylation of water-soluble iron porphyrin. Inorg Chem 42: 1945-51. (2003).

109. A novel mechanism underlying the susceptibility of neuronal cells to nitric oxide: the occurrence and regulation of protein
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110. Effect of nitric oxide on the ligand-binding activity of albumin. Arch Biochem Biophys 345: 237-42. (1997).

111. Nitric oxide inactivates rat hepatic methionine adenosyltransferase In vivo by S-nitrosylation. Hepatology 28: 1051-7. (1998).

112. Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism. Cardiovasc Res 72(1):80-9 (2006).

113. S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents.
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114. Neuronal nitric oxide synthase induced S-nitrosylation of H-Ras inhibits calcium ionophore-mediated extracellular signal-regulated kinase activity.
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115. S-nitrosylation and S-glutathiolation of protein sulfhydryls by S-nitroso glutathione. Arch Biochem Biophys 362: 67-78. (1999).

116. Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: Convergences and divergences. Cardiovasc Res 75(2):220-8. (2007).

117. Rapid nitric oxide-mediated S-nitrosylation of estrogen receptor: regulation of estrogen-dependent gene transcription.
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118. Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo. J Biol Chem 279: 36192-200. (2004).

119. Unbiased identification of cysteine S-nitrosylation sites on proteins. Nat Protoc 2: 1685-91. (2007).

120. Ca2+ pool emptying stimulates Ca2+ entry activated by S-nitrosylation. J Biol Chem 273: 30855-8. (1998).

121. Detection and proteomic identification of S-nitrosylated proteins in endothelial cells. Arch Biochem Biophys 423: 192-9. (2004).

122. S-nitrosylation of viral proteins: molecular bases for antiviral effect of nitric oxide. IUBMB Life 48: 25-31. (1999).

123. S-nitrosylation of cysteine 289 of the AT(1) receptor decreases its binding affinity for angiotensin II. Br J Pharmacol 148(3):306-13. (2006).

124. Nitric oxide inhibits ADP-ribosyl cyclase through a cGMP-independent pathway in airway smooth muscle.
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125. Cysteine nitrosylation inactivates the HIV-1 protease. Biochem Biophys Res Commun 250: 575-6. (1998).

126. TNFalpha and oxLDL reduce protein S-nitrosylation in endothelial cells. J Biol Chem 276: 41383-7. (2001).

127. S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron 46: 533-40. (2005).

128. Enhancement of S-nitrosylation in glycosylated hemoglobin. Biochem Biophys Res Commun 271: 217-21. (2000).

129. S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery.
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130. Emerging Roles of S-Nitrosylation in Protein Misfolding and Neurodegenerative Diseases. Antioxid Redox Signal 10(1):87-102 (2008).

131. Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages.
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132. S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity.
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133. Regulation of platelet granule exocytosis by S-nitrosylation. Proc Natl Acad Sci U S A 102: 3782-7. (2005).

134. Effect of nitric oxide in amyloid fibril formation on transthyretin-related amyloidosis. Biochemistry 44: 11122-9. (2005).

135. Nitric oxide-mediated inhibition of Hdm2-p53 binding. Biochemistry 41: 13570-4. (2002).

136. Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science 279: 234-7. (1998).

137. Screening for nitric oxide-dependent protein-protein interactions. Science 301: 657-61. (2003).

138. Selective nitrosyl group transfer reaction to cytidine using oligonucleotides bearing S-nitrosothioguanosine.
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139. Mass spectrometry-based analyses for identifying and characterizing S-nitrosylation of protein tyrosine phosphatases.
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140. Oxidative stress and S-nitrosylation of proteins in cells. Br J Pharmacol 129: 953-60. (2000).

141. Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme. J Biol Chem 276: 42138-45. (2001).

142. Proteomic identification of s-nitrosylated proteins in endothelial cells. Methods Mol Biol 357: 215-24. (2006).

143. Activation of RAS upregulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J Biol Chem 281(45):33939-48. (2006).

144. S-nitrosylation: spectrum and specificity. Nat Cell Biol 3: E46-9. (2001).

145. S-nitrosylation regulates apoptosis. Nature 388: 432-3. (1997).

146. Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron.
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147. Inhibition of nitrosylation, nitration, lymphocyte proliferation, and gene expression in acute and delayed cardiac allograft rejection
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148. Nitrosylation of thiols in vascular homeostasis and disease. Curr Atheroscler Rep 7: 213-8. (2005).

149. Ca(2+) entry activated by S-nitrosylation. Relationship to store-operated ca(2+) entry. J Biol Chem 274: 35318-24. (1999).

150. Redox modulation of the NMDA receptor by NO-related species. Prog Brain Res 118: 73-82. (1998).

151. S-nitrosylation TRiPs a calcium switch. Nat Chem Biol 2: 570-1. (2006).

152. A central role for S-nitrosylation in apoptosis. Nat Cell Biol 7: 645-6. (2005).

153. Inhibition of suicidal erythrocyte death by nitric oxide. Pflugers Arch [Epub ahead of print]. (2007).

154. Biological significance of nitric oxide-mediated protein modifications. Am J Physiol Lung Cell Mol Physiol 287: L262-8. (2004).

155. Down-regulation of nuclear receptor DNA-binding activity by nitric oxide--HNF4 as a model system. Med Sci Monit 8: RA217-20. (2002).

156. Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.
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157. Increased protein nitrosylation in head and neck squamous cell carcinogenesis. Head Neck 22: 64-70. (2000).

158. Nitric oxide modulation of voltage-gated calcium current by S-nitrosylation and cGMP pathway in cultured rat hippocampal neurons.
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159. cGMP and S-nitrosylation: two routes for modulation of neuronal excitability by NO. Trends Neurosci 25: 510-7. (2002).

160. Nitrosylation. the prototypic redox-based signaling mechanism. Cell 106: 675-83. (2001).

161. Fas ligand-induced apoptosis is regulated by nitric oxide through the inhibition of fas receptor clustering and the nitrosylation of
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162. Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation. FEBS Lett 579: 6115-20. (2005).

163. Nitric oxide negatively regulates Fas CD95-induced apoptosis through inhibition of ubiquitin-proteasome-mediated degradation of
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164. Signal transduction by nitric oxide in cellular stress responses. Mol Cell Biochem 234: 11-8. (0).

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166. Detection of cysteine S-nitrosylation and tyrosine 3-nitration in kidney proteins. Methods Mol Med 86: 373-84. (2003).

167. Nitric oxide block of outward-rectifying K+ channels indicates direct control by protein nitrosylation in guard cells.
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173. Nitric Oxide-Dependent Suppression of Thioredoxin-Interacting Protein Expression Enhances Thioredoxin Activity.
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176. Inhibition of the catalytic activity of rhodanese by S-nitrosylation using nitric oxide donors. Int J Biochem Cell Biol
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177. Neuronal protection and destruction by NO. Cell Death Differ 6: 943-51. (1999).

178. Calcium regulates S-nitrosylation, denitrosylation, and activity of tissue transglutaminase. Biochemistry 40: 4904-10. (2001).

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182. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell 116: 617-28. (2004).

183. Decomposition of protein nitrosothiolsin matrix-assisted laser desorption/ionization and electrospray ionization
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184. Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation. Proc Natl Acad Sci U S A 101: 8945-50. (2004).

185. Nitric oxide promotes endothelial cell survival signaling through S-nitrosylation and activation of dynamin-2.
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186. Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo.
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187. Cardiac capsaicin-sensitive sensory nerves regulate myocardial relaxation via S-nitrosylation of SERCA: role of peroxynitrite.
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188. S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide
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189. Nipradilol inhibits apoptosis by preventing the activation of caspase-3 via S-nitrosylation and the cGMP-dependent pathway.
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190. Regulation of beta cell glucokinase by S-nitrosylation and association with nitric oxide synthase. J Cell Biol 161: 243-8. (2003).

191. Concentration-dependent Effects of Nitric Oxide on Angiogenesis of Lung Microvascular Endothelial Cells: Role of Calpain Nitrosylation.
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