| Home | About us | Contact us | Our Team | Help |
 |
| p53 Database | ||||||||||||||
|
|
||||||||||||||
p53 Structures |
||||||||||||||
|
|
||||||||||||||
|
Detail Information of p53 in Homo sapiens:
| Gene Symbol | Tp53 |
| Gene Name | tumor protein p53 |
| Aliases | TP53; LFS1; TRP53 |
| Gene Id | 7157 |
| Gene Type | protein coding |
| Accession No | AF307851 |
| Molecular Weight | 43712(Da) |
| Expression | Ubiquitous |
| Taxonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo |
| Organism | Homo sapiens |
| Location | 17p13.1 |
| Description | Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome |
| Homology | Mouse, Rat |
| Related Disease | Adrenocortical carcinoma, pediatric,Breast cancer, Choroid plexus papilloma, Colon tumors, concurrent multiple primary, Hepatoblastoma, Hepatocellular carcinoma, Histiocytoma, malignant fibrous, Li-Fraumeni syndrome, LI-Fraumeni syndrome 1, Multiple malignancy syndrome, Nasopharyngeal carcinoma, Osteosarcoma, Osteosarcoma, multifocal, Pancreatic cancer |
| Pathways | Amyotrophic lateral sclerosis (ALS), Apoptosis, Basal cell carcinoma, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, Glioma, Huntington's disease, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Prostate cancer, Small cell lung cancer, Thyroid cancer, Wnt signaling pathway, |
| Molecular Class | Transcription factor |
| Molecular Function | ATP binding, DNA strand annealing activity, copper ion binding, enzyme binding, metal ion binding, nuclease activity, protein N-terminus binding, protein binding, protein heterodimerization activity, transcription factor activity, zinc ion binding |
| Biological Process | DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, ER overload response, apoptosis, base-excision repair, caspase activation via cytochrome c, cell aging, cell cycle, cell cycle arrest, cell differentiation, cell proliferation, cellular response to glucose starvation, induction of apoptosis by intracellular signals, multicellular organismal development, negative regulation of cell growth, negative regulation of helicase activity, negative regulation of progression through cell cycle, nucleotide-excision repair, protein complex assembly, protein localization, protein tetramerization, regulation of apoptosis, regulation of mitochondrial membrane permeability, regulation of transcription, DNA-dependent, transcription |
| Cell Component | cytoplasm, endoplasmic reticulum, insoluble fraction, mitochondrion, nuclear matrix, nucleolus, nucleoplasm, nucleus |
| Tissue Specificity | Lung biopsy |
| Genome length | 1182 nt |
| AA Length | 393 aa |
| Genome Sequence | atggaggagccgcagtcagatcctagcgtcgagccccctctgagtcaggaaacattttca gacctatggaaactacttcctgaaaacaacgttctgtcccccttgccgtcccaagcaatg gatgatttgatgctgtccccggacgatattgaacaatggttcactgaagacccaggtcca gatgaagctcccagaatgccagaggctgctccccccgtggcccctgcaccagcagctcct acaccggcggcccctgcaccagccccctcctggcccctgtcatcttctgtcccttcccag aaaacctaccagggcagctacggtttccgtctgggcttcttgcattctgggacagccaag tctgtgacttgcacgtactcccctgccctcaacaagatgttttgccaactggccaagacc tgccctgtgcagctgtgggttgattccacacccccgcccggcacccgcgtccgcgccatg gccatctacaagcagtcacagcacatgacggaggttgtgaggcgctgcccccaccatgag cgctgctcagatagcgatggtctggcccctcctcagcatcttatccgagtggaaggaaat ttgcgtgtggagtatttggatgacagaaacacttttcgacatagtgtggtggtgccctat gagccgcctgaggttggctctgactgtaccaccatccactacaactacatgtgtaacagt tcctgcatgggcggcatgaaccggaggcccatcctcaccatcatcacactggaagactcc agtggtaatctactgggacggaacagctttgaggtgcgtgtttgtgcctgtcctgggaga gaccggcgcacagaggaagagaatctccgcaagaaaggggagcctcaccacgagctgccc ccagggagcactaagcgagcactgcccaacaacaccagctcctctccccagccaaagaag aaaccactggatggagaatatttcacccttcagatccgtgggcgtgagcgcttcgagatg ttccgagagctgaatgaggccttggaactcaaggatgcccaggctgggaaggagccaggg gggagcagggctcactccagccacctgaagtccaaaaagggtcagtctacctcccgccat aaaaaactcatgttcaagacagaagggcctgactcagactga |
| AA Sequence | MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD |
| Domains | MCNSSCMGGMNRR |
| Motifs | QSDPSVEPPLSQETFSDLWKLLPEN, PGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWP, SSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTR VRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVP YEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRT EEENL, MCNSSCMGGMNRR, PKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEP |