p53 Isofoms in Homo sapiens

Gene Symbol	PPM1D
Gene Name	protein phosphatase 1D magnesium-dependent, delta isoform
Taxomomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Aliases	PP2C-DELTA, WIP1
Position	17q23.2
Gene ID	8493
Molecular Weight	66675
Expression	Liver
Homology	Mouse, rat
Molecular function	hydrolase activity, magnesium ion binding, manganese ion binding, protein phosphatase type 2C activity, protein phosphatase type 2C activity
Biological process	G2/M transition of mitotic cell cycle, cell cycle, negative regulation of cell proliferation, protein amino acid dephosphorylation, protein amino acid dephosphorylation, regulation of progression through cell cycle, response to bacterium, response to radiation
component	nucleus
AA Seq	MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAV AAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCA AIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRA VEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWS YDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKML VNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVK SLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSL NNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSG AQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC
NT Seq	GTACAAAAAAGCAGGCTCCACCATGGCGGGGCTGTACTCGCTGGGAGTGAGCGTCTTCTCCGACCAGGGC GGGAGGAAGTACATGGAGGACGTTACTCAAATCGTTGTGGAGCCCGAACCGACGGCTGAAGAAAAGCCCT CGCCGCGGCGGTCGCTGTCTCAGCCGTTGCCTCCGCGGCCGTCGCCGGCCGCCCTTCCCGGCGGCGAAGT CTCGGGGAAAGGCCCAGCGGTGGCAGCCCGAGAGGCTCGCGACCCTCTCCCGGACGCCGGGGCCTCGCCG GCACCTAGCCGCTGCTGCCGCCGCCGTTCCTCCGTGGCCTTTTTCGCCGTGTGCGACGGGCACGGCGGGC GGGAGGCGGCACAGTTTGCCCGGGAGCACTTGTGGGGTTTCATCAAGAAGCAGAAGGGTTTCACCTCGTC CGAGCCGGCTAAGGTTTGCGCTGCCATCCGCAAAGGCTTTCTCGCTTGTCACCTTGCCATGTGGAAGAAA CTGGCGGAATGGCCAAAGACTATGACGGGTCTTCCTAGCACATCAGGGACAACTGCCAGTGTGGTCATCA TTCGGGGCATGAAGATGTATGTAGCTCACGTAGGTGACTCAGGGGTGGTTCTTGGAATTCAGGATGACCC GAAGGATGACTTTGTCAGAGCTGTGGAGGTGACACAGGACCATAAGCCAGAACTTCCCAAGGAAAGAGAA CGAATCGAAGGACTTGGTGGGAGTGTAATGAACAAGTCTGGGGTGAATCGTGTAGTTTGGAAACGACCTC GACTCACTCACAATGGACCTGTTAGAAGGAGCACAGTTATTGACCAGATTCCTTTTCTGGCAGTAGCAAG AGCACTTGGTGATTTGTGGAGCTATGATTTCTTCAGTGGTGAATTTGTGGTGTCACCTGAACCAGACACA AGTGTCCACACTCTTGACCCTCAGAAGCACAAGTATATTATATTGGGGAGTGATGGACTTTGGAATATGA TTCCACCACAAGATGCCATCTCAATGTGCCAGGACCAAGAGGAGAAAAAATACCTGATGGGTGAGCATGG ACAATCTTGTGCCAAAATGCTTGTGAATCGAGCATTGGGCCGCTGGAGGCAGCGTATGCTCCGAGCAGAT AACACTAGTGCCATAGTAATCTGCATCTCTCCAGAAGTGGACAATCAGGGAAACTTTACCAATGAAGATG AGTTATACCTGAACCTGACTGACAGCCCTTCCTATAATAGTCAAGAAACCTGTGTGATGACTCCTTCCCC ATGTTCTACACCACCAGTCAAGTCACTGGAGGAGGATCCATGGCCAAGGGTGAATTCTAAGGACCATATA CCTGCCCTGGTTCGTAGCAATGCCTTCTCAGAGAATTTTTTAGAGGTTTCAGCTGAGATAGCTCGAGAGA ATGTCCAAGGTGTAGTCATACCCTCAAAAGATCCAGAACCACTTGAAGAAAATTGCGCTAAAGCCCTGAC TTTAAGGATACATGATTCTTTGAATAATAGCCTTCCAATTGGCCTTGTGCCTACTAATTCAACAAACACT GTCATGGACCAAAAAAATTTGAAGATGTCAACTCCTGGCCAAATGAAAGCCCAAGAAATTGAAAGAACCC CTCCAACAAACTTTAAAAGGACATTAGAAGAGTCCAATTCTGGCCCCCTGATGAAGAAGCATAGACGAAA TGGCTTAAGTCGAAGTAGTGGTGCTCAGCCTGCAAGTCTCCCCACAACCTCACAGCGAAAGAACTCTGTT AAACTCACCATGCGACGCAGACTTAGGGGCCAGAAGAAAATTGGAAATCCTTTACTTCATCAACACAGGA AAACTGTTTGTGTTTGCTAGGACCCAGCTTTCTTGTAC

Gene Symbol	PPP2R2B
Gene Name	protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
Taxomomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Aliases	PP2C-DELTA, WIP1
Position	5q31-q32
Gene ID	5521
Molecular Weight	66675
Expression	Liver
Homology	Mouse, rat
Molecular function	protein phosphatase type 2A regulator activity
Biological process	cell death, signal transduction
component	protein phosphatase type 2A complex
AA Seq	MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVY STFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLR DPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNI VDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEI ISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSD SVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAW HPSENIIAVAATNNLYIFQDKVN
NT Seq	GTACAAAAAAGCAGGCTCCACCATGGAGGAGGACATTGATACCCGCAAAATCAACAACAGTTTCCTGCGC GACCACAGCTATGCGACCGAAGCTGACATTATCTCTACGGTAGAATTCAACCACACGGGAGAATTACTAG CGACAGGGGACAAGGGGGGTCGGGTTGTAATATTTCAACGAGAGCAGGAGAGTAAAAATCAGGTTCATCG TAGGGGTGAATACAATGTTTACAGCACATTCCAGAGCCATGAACCCGAGTTCGATTACCTGAAGAGTTTA GAAATAGAAGAAAAAATCAATAAAATAAGATGGCTCCCCCAGCAGAATGCAGCTTACTTTCTTCTGTCTA CTAATGATAAAACTGTGAAGCTGTGGAAAGTCAGCGAGCGTGATAAGAGGCCAGAAGGCTACAATCTGAA AGATGAGGAGGGCCGGCTCCGGGATCCTGCCACCATCACAACCCTGCGGGTGCCTGTCCTGAGACCCATG GACCTGATGGTGGAGGCCACCCCACGAAGAGTATTTGCCAACGCACACACATATCACATCAACTCCATAT CTGTCAACAGCGACTATGAAACCTACATGTCCGCTGATGACCTGAGGATTAACCTATGGAACTTTGAAAT AACCAATCAAAGTTTTAATATTGTGGACATTAAGCCAGCCAACATGGAGGAGCTCACGGAGGTGATCACA GCAGCCGAGTTCCACCCCCATCATTGCAACACCTTCGTGTACAGCAGCAGCAAAGGGACAATCCGGCTGT GTGACATGCGGGCATCTGCCCTGTGTGACAGGCACACCAAATTTTTTGAAGAGCCGGAAGATCCAAGCAA CAGATCATTTTTCTCTGAAATTATCTCTTCGATTTCGGATGTGAAGTTCAGCCACAGTGGGAGGTATATC ATGACCAGGGACTACTTGACCGTCAAAGTCTGGGATCTCAACATGGAAAACCGCCCCATCGAGACTTACC AGGTTCATGACTACCTCCGCAGCAAGCTGTGTTCCCTCTATGAAAATGACTGCATTTTTGATAAATTTGA GTGTGTGTGGAATGGGTCAGACAGTGTCATCATGACAGGCTCCTACAACAACTTCTTCAGGATGTTCGAC AGAAACACCAAGCGTGATGTGACCCTTGAGGCTTCGAGGGAAAACAGCAAGCCCCGGGCTATCCTCAAAC CCCGAAAAGTGTGTGTGGGGGGCAAGCGGAGAAAAGACGAGATCAGTGTCGACAGTCTGGACTTTAGCAA AAAGATCTTGCATACAGCTTGGCATCCTTCAGAAAATATTATAGCAGTGGCGGCTACAAATAACCTATAT ATATTCCAGGACAAGGTTAACTTGGACCCAGCTTTCTTGTAC

Gene Symbol	PPP2R5C
Gene Name	protein phosphatase 2, regulatory subunit B', gamma isoform
Taxomomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Aliases	B56G, MGC23064, PR61G
Position	14q32
Gene ID	5527
Expression	Liver
Homology	Mouse, rat
Molecular function	peptidase activity, protein binding, protein phosphatase type 2A regulator activity, protein phosphatase type 2A regulator activity
Biological process	protein processing, signal transduction, signal transduction
component	integral to membrane, nucleus, protein phosphatase type 2A complex
AA Seq	MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKR AALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEF FLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYR FIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDST LTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYW NNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK LKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKKDR PLARRKSELPQDPHTKKALEAHCRADELASQDGR
NT Seq	Go to nucleotide sequence

Gene Symbol	PPP2CA
Gene Name	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Taxomomy	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Aliases	PP2Ac, PP2CA, RP-C
Position	5q31.1
Gene ID	5515
Expression	Liver
Homology	Mouse, rat
Molecular function	hydrolase activity, iron ion binding, manganese ion binding, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein heterodimerization activity
Biological process	RNA splicing, ceramide metabolic process, inactivation of MAPK activity, induction of apoptosis
component	cytoplasm, cytosol, nucleus
AA Seq	MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFR IGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNA NVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWG ISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDD TLKYSFLQFDPAPRRGEPHVTRRTPDYFL
NT Seq	Go to nucleotide sequence