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Knowledge of complete virus genome sequences helps biologists to develop a fundamental understanding of viral replication and host pathogen interactions. However, the consistence analysis of viral proteins in the absence of many of today's bioinformatics approaches has resulted in the level of organization and annotation of viral genome sequence consistence to grow. Additional complete protein sequences can be retrieve a single FASTA format files for easy import into other sequence analysis program. The protein families are a rich source of information for functional and evolutionary studies and the alignment of conserved sequences regions facilitate the direct study of construction of sequence profile.

The Hepatitis Virus Database, a knowledge-base of different hepatitis virus genes and proteins that contains detailed information of the genes and predicted protein sequences from 11 completely sequenced genomes (Hepatitis A Virus, Hepatitis B Virus, Hepatitis C Virus-6 genotypes, Hepatitis D Virus, Hepatitis E Virus, Hepatitis GVirus). Out of 11 genomes of hepatitis virus, the one genome (hepatitis virus C genotype 2) has shown the maximum length i.e. about 9,711 nt long and one virus (hepatitis D virus) has shown the minimum length i.e.