Bioinformatics Research Laboratory, IBI Biosolutions Pvt. Ltd. India

Data statistics

DB-DRD4 Database contains 254 sequences from 69 organisms and synthetic construct, including mammals, aves, pisces,and bacteria. Each entry in the database will be searchable by Genbank accession number.

The figures list below showing the information related to sequences and their hit with GPCR Signature, Profile and Transmembrane Region:

Information Related to 254 DRD4 Sequences with GPCR Signature and Transmembrane Region
Total Number of Sequences in 69 species + Synthetic Construct	254
Sequences with GPCR Signature and Transmembrane Region	65
Sequences with GPCR Profile	3
Sequences with GPCR Profile and Transmembrane Region	28
Sequences with Transmembrane Region	8
Sequences with no hit	150
Stastical Data of Sequences showing Percent Information related to Hit or No hit

 

Information Related to 254 DRD4 Sequences with number of Transmembrane Region (0-7)
Total Number of Sequences in 69 species + Synthetic Construct	254
Sequences with Number of Transmembrane Region : 0	154
Sequences with Number of Transmembrane Region : 1	33
Sequences with Number of Transmembrane Region : 2	20
Sequences with Number of Transmembrane Region : 3	1
Sequences with Number of Transmembrane Region : 4	3
Sequences with Number of Transmembrane Region : 5	4
Sequences with Number of Transmembrane Region : 6	8
Sequences with Number of Transmembrane Region : 7	30
Stastical Data of Sequences showing Percent Information related to Number of Transmembrane Region found in DRD4 sequences

 

Information Related to 254 DRD4 Sequences with GPCR Signature
Total Number of Sequences in 69 species + Synthetic Construct	254
Sequences with GPCR Signature	65
Sequences with GPCR Profile but No Signature	31
Sequences with No GPCR Signature	158
Stastical Data of Sequences showing Percent Information related to GPCR Signature found in DRD4 sequences

 

Information Related to Bacterial DRD4 Sequences with GPCR Signature and Transmembrane Region
Total Number of Sequences in 2 Bacterial species	4
Sequences with GPCR Signature and Transmembrane Region	0
Sequences with GPCR Profile	0
Sequences with GPCR Profile and Transmembrane Region	0
Sequences with Transmembrane Region	2
Sequences with no hit	2
Stastical Data of Sequences showing Percent Information related to Hit or No hit

 

Information Related to Pisces DRD4 Sequences with GPCR Signature and Transmembrane Region
Total Number of Sequences in 3 Pisces species	11
Sequences with GPCR Signature and Transmembrane Region	11
Sequences with GPCR Profile	0
Sequences with GPCR Profile and Transmembrane Region	0
Sequences with Transmembrane Region	0
Sequences with no hit	0
Stastical Data of Sequences showing Percent Information related to Hit or No hit

 

Information Related to Aves DRD4 Sequences with GPCR Signature and Transmembrane Region
Total Number of Sequences in 8 aves species	12
Sequences with GPCR Signature and Transmembrane Region	3
Sequences with GPCR Profile	0
Sequences with GPCR Profile and Transmembrane Region	6
Sequences with Transmembrane Region	3
Sequences with no hit	0
Stastical Data of Sequences showing Percent Information related to Hit or No hit

 

Information Related to Mammals Excluding Homo sapiens DRD4 Sequences with GPCR Signature and Transmembrane Region
Total Number of Sequences in 55 mammalian (excluding Homo sapiens) species	129
Sequences with GPCR Signature and Transmembrane Region	39
Sequences with GPCR Profile	0
Sequences with GPCR Profile and Transmembrane Region	21
Sequences with Transmembrane Region	2
Sequences with no hit	67
Stastical Data of Sequences showing Percent Information related to Hit or No hit

 

Information Related to Homosapiens DRD4 Sequences with GPCR Signature and Transmembrane Region
Total Number of Sequences in Homo sapiens species	94
Sequences with GPCR Signature and Transmembrane Region	8
Sequences with GPCR Profile	3
Sequences with GPCR Profile and Transmembrane Region	2
Sequences with Transmembrane Region	1
Sequences with no hit	80
Stastical Data of Sequences showing Percent Information related to Hit or No hit

 

Information Related to Synthetic Construct DRD4 Sequences with GPCR Signature and Transmembrane Region
Total Number of Sequences in Synthetic Construct	4
Sequences with GPCR Signature and Transmembrane Region	4
Sequences with GPCR Profile	0
Sequences with GPCR Profile and Transmembrane Region	0
Sequences with Transmembrane Region	0
Sequences with no hit	0
Stastical Data of Sequences showing Percent Information related to Hit or No hit

 

Recapitulate of the Work

Inspite of above information, there are numerous DRD4 Sequences of various organism, mostly of Homo sapiens showed no hit with GPCR Signature and Transmembrane Region, still they are considered under DRD4 sequences.     Literature related to DRD4 receptor proved that these sequences exactly show the pattern of DRD4 Exon1 and 3 region but this sequence information is not available on Pfam, prodom, prosite searching engine. Besides, the consensus pattern of the DRD4 sequence is also not available.So, we are just trying to interpret the consensus pattern of Dopamine D4 Receptor, as this is related to many neural disorders.