All organisms consist of cells that multiply through cell division. An adult human being has approximately 100 000 billion cells, all originating from a single cell, the fertilized egg cell. In adults there is also an enormous number of continuously dividing cells replacing those dying. Before a cell can divide it has to grow in size, duplicate its chromosomes and separate the chromosomes for exact distribution between the two daughter cells. These different processes are coordinated in the cell cycle. The cell cycle is the process by which cells duplicate themselves, grow, and prepare to divide again. It is the basis for the reproduction and sustained growth of all living organisms, and its control is also important for the proper understanding of cancer, because cancer can occur when cell cycle regulation fails. In recent years the basic mechanisms underlying cell cycle control have been unravelled, and shown to be common to living organisms from yeast to humans.

KEGG (Kyoto Encyclopedia of Genes and Genomes) connects known information on molecular interaction networks, such as pathways and complexes (this is the Pathway Database). There are 7 mammals, whose Cell Cycle Pathway is reported in KEGG. It is found that, 76 genes involved in cell cycle of Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos Taurus, Canis familiaris and Sus scrofa.When we go to find the information about these genes, we found molecular information for 73 gene in homo sapiens, 72 gene in Mus musculus, 69 gene in Rattus norvegicus, 55 gene in Pan troglodytes, 49 gene in Bos Taurus, 69 gene in Canis familiaris, 8 gene in Sus scrofa. Hence, the Motive and Goal of this project entitled "Comparative Analysis of Cell Cycle Genes of Homo Sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Bos Taurus, Canis familiaris, Sus Scrofa" is clear why we consider these 7 mammals and what we are going to analyze. So, to find-out the information about these uncharacterized genes in cell cycle of these organisms we use comparative analysis apparoach to find the sequences (based on similarity), and determine their functionality. We use various tools and databases through out this project. On the basis of the comparative analysis approach we putatively determine all genes in cell cycle except 3 genes; Mps1, Bub2, MEN because these genes are not reported in KEGG or any other database, and we are not able to find similarity of these genes with any other gene available in databases.

We have tried to compile this information system as much as interactive and useful from study and research point of view. Unique collection of all the information of Genes involved in Cell Cycle of and different role they play at a place is its specialty. It provides the maximum possible updated information about genes involved in cell cycle of these organisms.The incorporation of generally applicable Bioinformatics tools for the analysis of these mammals cell cycle makes it really useful.